Welcome to the Best Western Santa Fe Inn, an ideal Interstate and Airport property. We offer great comfort to our business and leisure travelers. The Best Western Santa Fe Inn is a central location to many of the Texas Panhandle tourist attractions. It makes it the perfect choice for all families traveling along Route 66. The Best Western Santa Fe Inn is conveniently located just minutes away from Water and Amusement Parks, the Quarter Horse Museum, and the famous Big Texan restaurant. The hotel is only a convenient 20 minutes away from the beautiful Palo Duro Canyon. Located 3.5 miles away from the Amarillo International Airport, the Best Western Santa Fe Inn is a perfect choice for the corporate business traveler. Our attentive, multilingual staff takes pride in providing exceptional service to our guest. We look forward to seeing you soon